Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis
Identifieur interne : 002522 ( Main/Exploration ); précédent : 002521; suivant : 002523Intravenous immunoglobulin therapy in a patient with lupus serositis and nephritis
Auteurs : M. Meissner ; Y. Sherer [États-Unis] ; Y. Levy [États-Unis] ; H. Chwalinska-Sadowska ; P. Langevitz ; Y. Shoenfeld [États-Unis]Source :
- Rheumatology International [ 0172-8172 ] ; 2000-07-01.
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Abstract
Abstract: The use of intravenous immunoglobulin (IVIg) has been reported as an immunomodulating agent in several autoimmune diseases, including systemic lupus erythematosus (SLE). Herein we report a SLE patient with severe clinical presentation that included pericarditis, pleural effusion, nephrotic range proteinuria, leukopenia, and lymphopenia. The patient received one course of high-dose IVIg (2.8 g/kg body weight), and within a week of post-IVIg therapy, her condition significantly improved. One-month post-IVIg there were decreased proteinuria, elevated leukocytes and lymphocytes count, decrease in antinuclear and anti-dsDNA antibodies, and disappearance of pericarditis and pleuritis. This case demonstrates the efficacy of IVIg in severe SLE with various clinical manifestations.
Url:
DOI: 10.1007/s002960000053
Affiliations:
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